International Journal of Pure & Applied Bioscience (IJPAB)
Year : 2018, Volume : 6, Issue : 1
First page : (129) Last page : (135)
Article doi: http://dx.doi.org/10.18782/2320-7051.5427
Ameliorative Potential of Methanolic Extract of Colchicum luteum Against Oxidative Stress in Sodium Bicarbonate Induced Gout in Broiler Chicken
Rayeesa Ali1, Shayaib Ahmad Kamil1*, Masood Saleem Mir1, Muneeb U Rehman2,
Umar Amin1, Aazima Shah1, Insha Amin2 and Bisma Kashani1
1Division of Veterinary Pathology, 2Molecular Biology Lab, Division of Veterinary Biochemistry,
Faculty of Veterinary Sciences & Animal Husbandry, Sher-e-Kashmir University of Agricultural Science & Technology (SKUAST-K), Srinagar, Jammu and Kashmir 190006, India
*Corresponding Author E-mail: vetpathology006@gmail.com
Received: 12.08.2017 | Revised: 22.09.2017 | Accepted: 26.09.2017
ABSTRACT
Colchicum luteum is an herbal plant and has been found to possess numerous therapeutic properties. In this study, we used methanolic extract obtained from corms of Colchicum luteum against oxidative stress in sodium bicarbonate induced gout in broiler chicken model. A total of 72 day old broiler chicks were divided into 6 groups (I to VI, n12). Group I served as vehicle-treated control and was given drinking water by oral gavage. Group II and III were given Sodium Bicarbonate @ 2.5% and 5% respectively in drinking water. Group IV and V were provided with 2.5% and 5% Sodium Bicarbonate along with Colchicum luteum extract @ 50mg/kg body weight respectively. Group VI served as treatment control and was given Colchicum luteum extract @ 50mg/kg body weight alone. The protective effect of Colchicum luteum extract (CLE) against oxidative stress was investigated by assaying lipid peroxidation, Catalase, Superoxide dismutase and Xanthine oxidase. Intoxicated groups revealed oxidative stress which included increased levels of LPO and XO and decreased activity of CAT and SOD. All these parameters however, showed normal activity in the birds given Colchicum luteum extract. The data from the present study establish the protective role of CLE against Sodium bicarbonate induced oxidative damage.
Key words: Gout, Oxidative stress, Sodium Bicarbonate, Colchicum luteum extract
Full Text : PDF; Journal doi : http://dx.doi.org/10.18782
Cite this article: Rayeesa, A., Kamil, S.A., Mir, M.S., Rehman, M.U., Amin, U., Shah, A., Amin, I. and Kashani, B., Ameliorative Potential of Methanolic Extract of Colchicum luteum Against Oxidative Stress in Sodium Bicarbonate Induced Gout in Broiler Chicken, Int. J. Pure App. Biosci.6(1): 129-135 (2017). doi: http://dx.doi.org/10.18782/2320-7051.5427
