International Journal of Pure & Applied Bioscience (IJPAB)
Year : 2017, Volume : 5, Issue : 4
First page : (160) Last page : (163)
Article doi: http://dx.doi.org/10.18782/2320-7051.2604
Synthesis and Physico- Chemical Characterization of Biodegradable Poly-Lactic-Co- Glycolic Acid Nanoparticles
Arul S.1*, K. Vijayarani2, K. Kumanan3, V. Sukanya4, Thamizhannal M.5
1,2,3Department of Animal Biotechnology, 4Department of Veterinary Biochemistry
5Department of Meat Science and Technology, Madras Veterinary College, Chennai, India
*Corresponding Author E-mail: arulbiotech2009@gmail.com
Received: 17.02.2017 | Revised: 26.02.2017 | Accepted: 2.03.2017
ABSTRACT
Poly (lactic-co-glycolic acid) (PLGA) is a biocompatible member of the aliphatic polyester family of biodegradable polymers. PLGA has long been a popular choice for drug delivery applications, particularly; it is already FDA-approved for use in humans in the form of resorbable sutures. Hydrophobic and hydrophilic drugs are encapsulated in PLGA particles via single- or double-emulsion. The aim of the study is to evaluate the physico-chemical properties of Polylactidc-co-glycolic acid (PLGA) nanoparticles. Polylactic-co-glycolic acid (PLGA) nanoparticles were synthesized by Double emulsion solvent evaporation method at Department of Animal Biotechnology, Madras Veterinary College. The PLGA nanoparticles were synthesized lyophilized and quantified. The yield of PLGA nanoparticles was 19.2 %. The size of PLGA nanoparticles was measured in the scanning electron microscopy (SEM) and it was found to be 280- 320 nm. The polydispersity index (PDI) of PLGA nanoparticles was 0.192. Net surface charge of the nanoparticles was measured using zetasizer. The measured zeta potential of the PLGA nanoparticles was -2.61 mV.
Key words: PLGA nanoparticles, Biodegradability, Polydispersity index
Full Text : PDF; Journal doi : http://dx.doi.org/10.18782
Cite this article: Arul, S., Vijayarani, K., Kumanan, K., Sukanya, V., Thamizhannal, M., Synthesis and Physico- Chemical Characterization of Biodegradable Poly-Lactic-Co- Glycolic Acid Nanoparticles , Int. J. Pure App. Biosci.5(4): 160-163 (2017). doi: http://dx.doi.org/10.18782/2320-7051.2604
