International Journal of Pure & Applied Bioscience (IJPAB)
Year : 2016, Volume : 4, Issue : 6
First page : (153) Last page : (158)
Article doi: http://dx.doi.org/10.18782/2320-7051.2405

Assessment of DNA Damage in Workers Exposed to Organic Solvents

K. Rudrama Devi*, K. Dilip Reddy and P. Minny Jael
Human Genetics and Molecular Lab, Department of Zoology, University College of Science,
Osmania University, Hyderabad – 07. Telangana, India
*Corresponding Author E-mail: rudrama_devi@yahoo.com
Received: 17.11.2016  |  Revised: 28.11.2016   |  Accepted: 30.11.2016  

Abstract
The carcinogenic potential of organic solvents is major issue in defining human health risk in occupationally settings. Hence in the present investigation 108 workers employed in shoe manufacturing factory Nacharam (Ranga Reddy District) and 82 control subjects with similar mean ages, smoking prevalences were selected for analysis of DNA damage in human lymphocytes by comet assay. The present study clearing indicated that chronic exposure to organic solvents in workplace induced significant increase frequencies were observed in smokers thus indicate synergistic effect of occupation exposure and smoking. To ensure maximum occupational safety, biomonitoring is of great value for assessing the risk in shoe- manufacturing workers. Thus DNA damage and cellular death are known to the important mechanism in chemical carcinogenesis. These results may be relevant in risk assessment for protecting human health and preventing carcinogenesis.

Key words: DNA damage, comet assay, organic solvents. 

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Rudrama, D.K., Reddy, K.D. and Jael, P.M., Assessment of DNA Damage in Workers Exposed to Organic Solvents, Int. J. Pure App. Biosci.4(6): 153-158 (2016). doi: http://dx.doi.org/10.18782/2320-7051.2405