International Journal of Pure & Applied Bioscience (IJPAB)
Year : 2016, Volume : 4, Issue : 2
First page : (340) Last page : (345)
Article doi: http://dx.doi.org/10.18782/2320-7051.2267

Homology Modeling and physiochemical analysis of Toxic Protein Verotoxin and its Model Validation

Anil K. Singh*
Environmental Toxicology Group, CSIR-Indian Institute of Toxicology Research Lucknow, U.P., 226010, India
*Corresponding Author E-mail: phd.anil@yahoo.com
Received: 10.03.2016  |  Revised: 18.03.2016   |  Accepted: 23.03.2016  

Abstract
verotoxin is a toxin produced by some strain of Escherichia coli bacteria. Verotoxin also known as Shiga-like toxin. Two types are of verotoxin are known as SLT1 and SLT2.  The verotoxin or shiga-like toxin associated with hemolytic-uremic syndrome in human. This toxin is a multi-subunit protein made up one molecule of A subunit responsible for the toxic action, while other five molecules of the B unit responsible for binding to a specific cell’s receptor. Present study is being performed towards understand and structure prediction of this toxic protein. Verotoxin structures of both subunits are being predicted through homology modeling. Three dimensional structures are being predicted and validate through various online modeling tools and server.

Keyword:protein modeling, structure prediction, toxic protein, in silico, validation.

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Singh, A.K., Homology Modeling and physiochemical analysis of Toxic Protein Verotoxin and its model validation, Int. J. Pure App. Biosci.4(2): 340-345 (2016). doi: http://dx.doi.org/10.18782/2320-7051.2267