International Journal of Pure & Applied Bioscience (IJPAB)
Year : 2016, Volume : 4, Issue : 2
First page : (17) Last page : (26)
Article doi: http://dx.doi.org/10.18782/2320-7051.2244
Comparıson of the Diagnostıc Value of HbA1c with Fructosamıne in Dıabetes Mellitus
Hesna URAL KAYALIK1*, Tuba CANDAR2, Selda DEMİRTAS2 and Sema CETIN3
1Ufuk University, Vocational School of Health Services, Ankara, TURKEY
2Ufuk University, Faculty of Medicine, Department of Biochemistry, Ankara, TURKEY
3Kirikkale University, Faculty of Sciences and Literature, Department of Biology, Kirikkale, TURKEY
*Corresponding Author E-mail: drhesnaural@gmail.com
Received: 17.03.2016 | Revised: 22.03.2016 | Accepted: 28.03.2016
Abstract
HbA1c is the most widely used follow-up test for diabetes mellitus (DM) worldwide. Although the fructosamine test is not widely used, this test can also be useful for the follow-up of DM in the previous 2 weeks.
This study aimed to determine the effect of pathological conditions associated with heme abnormalities by measuring the hemoglobin content in patients with both iron-deficiency anemia and diabetes. To investigate pathological conditions associated with the globin content of hemoglobin, diabetic and prediabetic patients with thalassemia minor were also enrolled. The effects of thalassemia minor on HbA1c levels were evaluated, and serum fructosamine was assayed in both groups to evaluate the accuracy of the results.
Our results demonstrate that while HbA1c levels are altered as a result of hemoglobinopathies related to severe iron deficiency anemia or thalassemia, fructosamine results are not affected by these conditions in either diabetic or prediabetic patients. Furthermore, there was no relationship between HbA1c and fructosamine in either the diabetic or prediabetic groups. These results indicate that the HbA1c test is inadequate for the diagnosis and follow-up of DM patients with heme- or globin-related anomalies. The addition of the fructosamine test is suggested to improve the interpretation of the test results.
Full Text : PDF; Journal doi : http://dx.doi.org/10.18782
Cite this article: Kayalik, H.U., Candar, T., Demirtas, S. and Cetin, S., Comparıson of the Diagnostıc Value of HbA1c with Fructosamıne in Dıabetes Mellitus, Int. J. Pure App. Biosci. 4(2): 17-26 (2016). doi: http://dx.doi.org/10.18782/2320-7051.2244
