International Journal of Pure & Applied Bioscience (IJPAB)
Year : 2016, Volume : 4, Issue : 2
First page : (1) Last page : (8)
Article doi: http://dx.doi.org/10.18782/2320-7051.2232
Evaluation of Diclofenac effect on oxidative stressed mice
BENKHASSI Zoubair1*, LAHLOU Fatima Azzahra1, HMIMID Fouzia1, LOUTFI Mohammed1, BENAJI Brahim2 and BOURHIM Noureddine1
1Départementde biologie, laboratoirede Biochimieet Biologie Moléculaire Faculté des Sciences Ain Chock, Université Hassan II-Casablanca, km 8 route d’El Jadida BP. 5366 Casablanca, Morocco
2Ecole Normale Supérieur de l’Enseignement Technique- Université Mohammed V de Rabat – BP 2707 - Rabat, Morocco
*Corresponding Author E-mail: zoubair.benkhassi7@gmail.com
Received: 4.03.2016 | Revised: 15.03.2016 | Accepted: 18.03.2016
Abstract
Diclofenac (2-[(2,6-dichlorophenyl)amino]benzene acetic acid) Non-steroidal anti-inflammatory drug (NSAID) is among the most frequently used medical drug as analgesic, anti-inflammatory and antipyretic effect. This study aims to evaluate if Diclofenac has an antioxidant effect, relative to its analgesic antipyretic and anti-inflammatory activities, or it possesses a cytotoxic potential. Oxidative stress was induced by intraperetoneal injection of peroxide hydrogen (H2O2), and then a comparative study is made concerning the activities of the antioxidant enzymes SOD, CAT, GR, SDH as well as MDA lipid peroxidation levels in liver. An decrease in SOD, CAT, GR, SDH activity and MDA lipid peroxidation in mice treated with H2O2 accompanied by Diclofenac; compared to the group treated by L-ascorbic acid + H2O2 showed that diclofenac show good antioxidant effect. Moreover this study has suggested that acetylsalicylic acid induced anti-inflammatory effects in liver mediated by decrease oxidative stress and restore redox reaction of metabolism.
Key words: Diclofenac, Oxidative stress, Antioxidant.
Full Text : PDF; Journal doi : http://dx.doi.org/10.18782
Cite this article: Zoubair, B., Azzahra, L.F., Fouzia, H., Mohammed, L., Brahim, B. and Noureddine, B., Evaluation of Diclofenac effect on oxidative stressed mice, Int. J. Pure App. Biosci. 4(2): 1-8 (2016). doi: http://dx.doi.org/10.18782/2320-7051.2232
