International Journal of Pure & Applied Bioscience (IJPAB)
Year : 2015, Volume : 3, Issue : 6
First page : (183) Last page : (191)
Article doi: http://dx.doi.org/10.18782/2320-7051.2175
Effects of the Biophytum sensitivum (L.) DC leaf extracts on anti-angiogenic properties by chorioallantoic membrane (CAM) assay
Manisha Mhaske* and Ghanshyam Gonjari1
*P.G. Dept.of zoology, Yashvantrao chavan institute of Science, Satara, 415001. India
1Director, Rayat institute of Research and Development(RIRD)- Satara, 415001- India
*Corresponding Author E-mail: mhaskemanisha2316@gmail.com
Abstract
Biophytum sensitivum (Linn) DC (Oxalidaceae) is a medicinal plant used as antitumor, radioprotective, antibacterial, antidiabetic and ayurvedic medicine. Antiangiogenic property of acetone extract of B. sensitivum (leaf) is evaluated by chick chorioallntoic membrane (CAM) assay in vivo. Treatment doses of leaf extracts were administered at 48, 72 and 96hrs of incubation by window method and observed for angiogenesis at 144hrs of development. The results by comparing with DNS control and normal embryo showed prominent antiangiogenic effect with significant reduction in number and area of tertiary vitelline veins. The inhibition of angiogenesis was highly significant at 48hrs. The role of metabolites acting by obstructing signaling of angiogenic agents from epithelial cells or may be inducing apoptosis is discussed for it’s anti-angiotherapantic use.
Key words: anti-angiogenesis, Biophytum sensitivum, chick chorioallntoic membrane (CAM) assay.
Full Text : PDF; Journal doi : http://dx.doi.org/10.18782
Cite this article: Mhaske, M. and Gonjari, G., Effects of the Biophytum sensitivum (L.) DC leaf extracts on anti-angiogenic properties by chorioallantoic membrane (CAM) assay, Int. J. Pure App. Biosci. 3(6): 183-191 (2015). doi: http://dx.doi.org/10.18782/2320-7051.2175
