International Journal of Pure & Applied Bioscience (IJPAB)
Year : 2015, Volume : 3, Issue : 5
First page : (26) Last page : (34)
Article doi: http://dx.doi.org/10.18782/2320-7051.2087

Human Herpes virus 8 Infection in Egyptian Hemodialysis Patients: Prevalence and Risk Factors

Reem Refat Abd  El-Glil*   and Abeer Ahmed Aboelazm
Microbiology & Immunology Department, Faculty of Medicine, Benha University, Egypt
*Corresponding Author E-mail: reemrefat07@hotmail.com
Abstract
Patients on maintenance hemodialysis (HD) have a high risk of blood-borne viral infections. Blood-borne transmission of Human herpes virus 8 (HHV-8) may exist. The possibility of high incidence of post transplantation Kaposi sarcoma (KS) might be the result of infection with HHV-8. The aim of this study was to determine the prevalence of HHV-8 in 60 uremic Egyptian patients on regular HD by polymerase chain reaction (PCR) compared to 30 healthy controls and study the role of associated risk factors. HHV-8 DNA was detected in peripheral blood mononuclear cells by PCR using primer sets located in the HHV-8 open reading frame 9-1(ORFK9-1).The prevalence of HHV-8 was significantly higher (p=0.029) in HD patients compared to the control group. The detection rate of HHV-8 DNA was significantly higher in older age (p=0.026), and longer duration of HD (p= 0.025). HHV-8 DNA detection rates were insignificantly different with patient sex, history of blood transfusion, patient education and residence. High prevalence of HHV-8 infection in HD patients supports the possibility of virus transmission in those patients via HD, or uremic patients are at risk of reactivation of HHV-8-latent infection.

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Abd El-Glil, R.R. and Aboelazm, A.A., Human Herpes virus 8 Infection in Egyptian Hemodialysis Patients: Prevalence and Risk Factors, Int. J. Pure App. Biosci. 3 (5): 26-34 (2015). doi: 10.18782/2320-7051.2087