International Journal of Pure & Applied Bioscience (IJPAB)
Year : 2015, Volume : 3, Issue : 5
First page : (178) Last page : (183)
Article doi: http://dx.doi.org/10.18782/2320-7051.2119

Antigenotoxic effects of Aegle marmelos Fruit Extract in Cyclophosphamide Induced Chromosomal Aberrations and Aberrant Sperms in Germ Cells of Swiss Albino Mice

Sushma Ch and K. Rudrama Devi*
Toxicogenomics, Department of Zoology, Osmania University, Hyderabad, Andhra Pradesh, India
*Corresponding Author E-mail: rudramadevi_k@yahoo.com
Abstract
The present investigation was attempted to study the possible anti-genotoxic activity of crude Aegle marmelos(AMF) fruit extract in cyclophosphamide-induced genotoxicity in mouse by using chromosomal aberrations (CA’s) in germ cells and sperm morphology essay (SMA). Three different doses of Aegles marmelos(200, 400, 600 mg/kg) were orally administered for their modulatory capacity on the mutagenecity exerted by CP (50 mg/kg, i.p.). AMF alone did not induce any significant variation in the incidence of CA’s and frequency of aberrant sperms. Pretreatment of mice with AMF for 7 days and simultaneously with a single dose of cyclophosphamide significantly reduced the frequency of CA’s and frequency of aberrant sperms, suggesting that the Aegles marmelosfruit extractmodulates the CP induced genotoxicity in a dose dependent manner. Thus the results clearly indicate the protective nature of Aegles marmelosfruit extract on cancer chemoprevative strategy.

Key words: Aegle marmelos, Chromosomal Aberrations, Aberrant Sperms, Germ Cells.

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Sushma, Ch. and Rudrama, D.K., Antigenotoxic effects of Aegle marmelos Fruit Extract in Cyclophosphamide Induced Chromosomal Aberrations and Aberrant Sperms in Germ Cells of Swiss Albino Mice, Int. J. Pure App. Biosci. 3 (5): 178-183 (2015). http://dx.doi.org/10.18782/2320-7051.2119