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The aim of the present study is to evaluate the effect of aqueous extract of plant Centella asiatica against
papilloma and melanoma tumours in Swiss Albino mice. Topical application of the Centella asiatica
extract at the dose of 500 and 1000 mg/kg body weight at the pre promotion phase showed a significant
reduction in tumor incidence, tumor burden, tumor weight, tumor size, cumulative number of papillomas.
Aqueous extract of Centella against melanoma cells in experimental mice two groups of C57BL hybrid
mice were maintained and orally pretreated at the doses of 500 and 1000mg/kg body weight for 30 days
showed increased activity in life span of animals and tumour volume was significantly reduced as
compare to control cell number, packed cell volume, decrease in tumour weight of the mice, increase in
life span .These observations are suggestive of the protective effect of Centella extract against papilloma
and melanoma tumours.
Keywords: Centella asiatica , papilloma ,melanoma, Anticancer agents.