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The present investigation was carried out with the aim to formulate and evaluate Fast/mouth dissolving
tablet of Olmesartan medoxomil by direct compression method. Olmesartan medoxomil is the novel antihypertensive
drug having specific angiotensin II type 1 antagonist activity and used in the management of
acute and chronic hypertension. Mostly hypertension found in geriatric patients who face difficulty in
swallowing (dysphagia). Olmesartan medoxomil drug have major problem of solubility in biological
fluids and first pass metabolism, which results into poor bioavailability (26%) after oral administration.
In the present work We had developedfast dissolving tablet of Olmesartan medoxomil 20 mg, using
synthetic and natural superdisintegrants like, Sodium starchglycolate, Croscarmellose, Crospovidone and
Plantagoovatamucilage in different concentrations (5, 7.5 and 10mg). The taste of drug was masked
usingaspartame as sweetening agent, Mannitolused as bulk forming agent. Other excipients used are talc
as a Glidant, and Magnesium stearate as lubricant. The prepared formulation batch of tablets were
evaluated for weight variation, tablet thickness, hardness, friability, drug content, wetting time, in vitro
dispersion time and in-vitro dissolution study and the batch F12 was observed as optimized. Effect of
disintegrant on disintegration behaviour of tabletwas evaluatedin artificial saliva and the compatibility
study was carried out using Infrared spectroscopy.
Keywords: Fast dissolving tablets, Olmesartan medoxomil,Plantagoovatamucilage, Superdisintegrants.