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To evaluate the toxic properties of Anti-Alzheimer’s drugs, such as Galantamine hydrobromide,
Physosigmine, Rivastigmine, Eptastigmine, Memantine, Xanomeline, Huperzine A and E2020 (AricepTM)
through Lipinski rule of Five. The Bioactivity properties and Drug-likeness of the above mentioned
selective Drugs were calculated using Molinspiration and Molsoft tools and their toxic properties were
determined by employing the Osiris server. Interestingly, after application of Lipinski’s rule of five, our
results revealed that all these selected drugs have fully satisfied the Lipinski’s rule of five and thus were
recommended as safe drugs for effective treatment of AD. In view of this, it has been suggested that
consumption of these Anti-Alzheimer’s drugs by children to improve their cognitive skills, may initially
exert positive effects on their performing capabilities, but in long run, might cause irreparable damage in
the brain which in turn will lead to deficits in cognitive functions of children.
Keywords: Anti-Alzheimer’s drugs, Lipinski’s rule of five, Molinspiration and Osiris softwares.