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The pharmaceutical industry demands innovation in short period of time so as to gain access to new
products in market. Formulation is all working with active ingredients and the excipients. The more
excipients more are steps involved in manufacturing and higher are the cost incurred on introducing
product to market. Excipients having multiple functions help to solve these issues as cost effective
paradigm are on top most priorities in the industry. The smart excipients are the multifunctional
excipients which are needed for continuous development and for much needed innovation. The existing
excipients have been modified, co-processed, modifications are made with existing ones or cross linked in
order to improve existing characteristics and impart good compatibility, flowability, dissolution,
disintegration, hygroscopicity, palatability to formulate new product with an aim to minimize cost
incurred on it. Multifunctional excipients like Ludipress®, F-MELT®, Galen IQ 721, MCC SANAQ®
burst etc. have been assigned to be the smart excipients that help in robust formulation development with
minimum problem during technological transfer.
Key words: excipients, multifunctional excipients, co-processed excipient, direct compression.