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Shea butter and carbohydrate rich diet in renal insufficiency of unilateral nephrectomised rabbits was
investigated in this study. Four groups of rabbits at which three nephrectomised rabbits were fed on
standard laboratory chow, protein replete diet and protein deficient diet respectively. The control group
was a sham operated and was maintained on standard laboratory chow, the diet and water inclusive adlibitum
was started a week of post–surgery stabilization period, their renal function status was assessed by
serum urea and creatinine estimation obtained from blood sample of the ear on a weekly bases. The result
range from week 1 to 12. Serum creatinine concentration (8.46±0.30 to 9.15 ±0.00; 9.04±0.08 to
12.98±0.28; 8.11±0.42 to 11.34±0.87; and 9.57±0.95 to 10.07±0.18) respectively for group A, B, C and D.
Serum urea concentration (20.30±0.30 to 18.48±0.01; 21.16±1.03 to 27.9 ±1.08; 24.17±5.08 to
40.85±3.27 and 21.45±0.44 to 22.13±0.75) respectively for group A, B, C and D shown significant
increase when compared to the control. The blood urea nitrogen ratio ranges between (11.21±0.57 to 9. 41
±0.00; 10.91±0.62 to 10.32±1.23; 13.76±2.53 to 16.84±1.17 and 10.52±0.76 to 10.23±0.21) respectively
for group A, B, C and D. Finding indicate that protein restricted diet slowed the loss of renal function,
while the protein replete diet (shea butter + carbohydrate diet) accelerated loss of renal function when
compared with the control.
Key words: Shea Butter, Carbohydrate, Urea, Creatinine.