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Healthy Albino Rats are reared feeding on pulses, gram and bread. After acclimatization these are
divided into one normal-control and three experimental groups. Type-2 diabetes mellitus is induced to
two of the experimental groups by injecting single dose of streptozotocin (60mg/kg body weight)
intraperitonialy 15 minutes after intraperitonial admistration of nicotinamide (120mg/kg body weight).
Oral administration of water- extract of Syzygium cumini seeds (400mg/kg body weight) are done to one
non-diabetic and one diabetic group of Rats throughout the study period.
Glucose tolerance test of the study animals are done after the study period of 4 weeks. Statistical analysis
of data revealed that water-extract of S. cumini seeds can successfully minimize hyperglycemia induced
by streptozotocin-nicotinamide administration.
Study of AST (Aspartate Transferase), ALT (Alanine Transferase) and ALP (Alkaline Phosphatase)
activities in blood samples and LPO (Lipid Peroxide), GST (Glutathione S-Transferase) and CYP
(Cytochrome p450) activities in liver samples of the study animals indicate that no major toxicity arise
from the administration of S. cumini seed-extract. Rather, it plays a hepatostimulant role.
Investigation of Urea, Creatinine and Uric Acid levels in blood samples of the study animals lead to a
conclusion that no nephrotoxicity occurs from the use of this ethno-medicinal component.
Keywords: Albino rat, diabetes, hepatotoxicity, nephrotoxicity.