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Thevetia peruviana belongs to the Apocynaceae family. Thevetia peruviana is commonly found in Asian countries, especially in India, Sri Lanka. That has been used as an anti-inflammatory, anti-microbial, and an anti-oxidant. The paper has made an attempt in presenting a comprehensive review of the fifteen years of extensive research conducted on this plant with respect to its clinical significance. A wide-ranging account of its phytoconstituents, Antioxidant, Antimicrobial and the clinical aspect are presented in this paper, In view of the many recent findings of importance with regards to this plant. A wide range of secondary metabolites have been isolated from this plant, exhibiting various and excessive array of biological activities. Extracts from the various parts of Thevetia peruviana possess useful pharmacological activities. In conclusion, Thevetia peruviana is a well studied plant of medicinal value. It has scientifically confirmed to show anti-microbial action from the oil of the plant that contains flavonoids and thevefolin isolated from seeds showed anti-cancer activity and cardiotonic activity. Plants also bearing non-edible seeds have the potentials of reclaiming wasteland and do not compete with food crops and using up of these non-conventional and non-edible feed stocks can be sustainable for biodiesel production.

Key words: Thevetia peruviana, Good luck tree, Phytochemical, Antioxidant, Antimicrobial.