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Mastitis is a multifactorial disease which is characterized by the inflammation of the parenchyma of mammary glands. The maximum new intramammary infections are acquired during the dry period. Therefore dry cow therapy is cornerstone for mastitis control in bovines. Dry cow therapy is use of intra-mammary antimicrobial therapy immediately after the last milking of lactation. It is implementation of the five-point plan for the mastitis control. It mainly aims on removing the prevailing intra-mammary infections and inhibiting new intramammary infections during the dry period. Recently, there is growing concern of indiscriminate use of antibiotics. Therefore, the non–antibiotic therapy, teat seals is gaining popularity and there is need of development for other new approaches for control of mastitis. This review focus on new bacterial infections during dry period and the various approaches involving control of mastitis.

Key words: Mastitis; Dry cow therapy; Intramammary; Teat seals