Archives

Development in the science is helping the people to have the knowledge of unknown things. In that
attempt, finding the plants as the best therapeutic option for the health problems and making them
familiar to the people. The present experiment was conducted for 7 days to evaluate the hepatoprotective
activity of Erythroxylum monogynum in CCl4 (1ml/kg) induced rats. The hydroalcoholic extract of plant
was prepared by maceration technique. The 5 group of rats were maintained as Control, CCl4 induced,
CCl4+ Liver tonic, CCl4+extract 150mg/kg and CCl4+extract 200mg/kg. On the 8th day blood was
collected by retro orbital puncture for the study of serum parameters like SGOT (Serum Glutamate
Oxaloacetate Transaminase), SGPT (Serum Glutamate Pyruvate Transaminase) and bilirubin. Then the
liver separated and processed for the histological studies. The decreased levels of SGOT, SGPT, total
bilirubin in the treated rats were an indication of the hepatoprotective activity of extract. The
regeneration of hepatocytes was also evidence for hepatoprotective activity of extracts.
Keywords: Hepatoprotective activity, SGOT, SGPT, Liver tonic, Necrosis.