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Niosomes are non-ionic surfactant vesicles obtained on hydration of synthetic nonionic surfactants, with
or without incorporation of cholesterol or other lipids. They are vesicular systems similar to liposomes
that can be used as carriers of amphiphilic and lipophilic drugs.
Niosomes are promising vehicle for drug delivery and being non-ionic; it is less toxic and improves the
therapeutic index of drug by restricting its action to target cells. This systemic review article deals with
preparation methods, characterizations, rationale, advantages, disadvantages, and applications of
niosomes. Niosomes are microscopic lamellar structures ranging between 10 to 1000 nm constitute of
non-ionic surfactant and cholesterol. Niosomes are preferred over liposome due to chemicals stability
and economy.
Keywords: Niosomes, non-ionic surfactants, liposomes.