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The present study designed to evaluate the Antiasthmatic activity of extract of Euphorbia hirta on in vitro
and in vivo animal model. Ethanolic extract of Euphorbia hirta was evaluated using in vitro goat tracheal
chain preparation model and Clonidine induced catalepsy in mice model. The extract was subjected to
phytochemical screening and found to contain essential oils, volatile oils, tannins, phenolics, flavonoids,
carbohydrates and resinous matters. Histamine induced contraction in isolated goat tracheal chain shows
that Ethanolic extract of Euphorbia hirta inhibited the contractile effect of histamine. Antiasthmatic
Activity was increased with the increasing concentration of extract. Presence of Phytochemical like
flavonoids, Glycosides,Saponine might contribute to the observed Antiasthmatic activity.
Keywords: Euphorbia hirta; Antiasthmatic Activity; Clonidine induced catalepsy; goat tracheal chain
preparations.