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Background:Hypothyroidism is the most common endocrine disorder especially in women. It isassociated
with increased risk for atherosclerosis and other complications. The frank development of hypothyroidism
is associated with metabolic derangements including dyslipidemia- which is an etiopathologic factor for
development of renal impairment. This study was to evaluate whether hypothyroidism is associated with
impaired renal function by measuring serum uric acid and creatinine levels. Aim of the study:To estimate
and compare serum creatinine and uric acid in healthy controls and hypothyroid patients.Materials and
Methods:A cross sectional analytical studyof 40 newly diagnosed and untreated cases of hypothyroidism
and 40 healthy controls in the age group of 18 - 60 years were included in whom 5mL of fasting blood
sample was drawn to estimate serum levels of T3, T4, TSH by Chemiluminiscence immuno assay. Uric
acid, Creatinine and lipid profile parameters were measured using automated clinical chemistry analyzer
according to manufacturer’s protocol. Results:There was significant increase in the levels of serum
creatinine and uric acid found in hypothyroid patients compare to healthy controls.
Keywords: Hypothyroidism, Thyroid stimulating hormone, Creatinine and Uric acid.