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Indian Journal of Pure & Applied Biosciences (IJPAB)
Year : 2020, Volume : 8, Issue : 6
First page : (442) Last page : (454)
Article doi: : http://dx.doi.org/10.18782/2582-2845.8445

Preliminary Screening of Anti-Microbial, Anti-Oxidant and Anti-Cancer Potential of Butea monosperma Flower Extracts

Shilpa Polina , Nagaraju Marka and Manohar Rao D.*
Department of Genetics, Osmania University, Hyderabad – 500 007, Telangana, India
*Corresponding Author E-mail: dmanoharrao27@gmail.com
Received: 23.10.2020 | Revised: 25.11.2020 | Accepted: 2.12.2020 

 ABSTRACT

Cancer an aggressive killer, even though there is a lot of development in cures and preventative therapies occur at global level still there is a need to develop effective, and affordable anti-cancer drugs. Butea monosperma, sacred tree, rich with various phyto constituents used as antimicrobial, anti-fertility, anticonvulsive, anti-helminthic, anti-diarrhoeal, wound healing, hepatoprotection, anti-hypertenstive, antitumor, anti-diabetic, and anti-inflammatory. In the present study, ethyl acetate, chloroform and methanol extracts of Butea monosperma flowers were screened for anti-microbial (agar well diffusion method), anti-oxidant (DPPH and TPC assay) and anti-cancer (MTT assay) activities. Among the three extracts, Ethyl acetate extract showed highest anti-bacterial (Bacillus subtilis, Staphylococcus aureus, E. Coli and Pseudomonas aeruginosa), anti fungal (Aspergillus niger), anti-oxidant (DPPH with IC50-29.64), total phenolic content (90.35mg GAE/g) and cyto-toxicity against MCF-7 cell lines (IC50-24.150µg/mL),  while methanol extract exhibited highest anti-fungal activity (Candida albicans) and cyto-toxicity against A-549 cell lines (IC50-15.288µg/mL). Whereas the chloroform extract relatively exhibited less activity compared to the other two extracts. These results clearly indicate that Butea monosperma flowers possess valuable phytochemicals to treat various diseases.

Key words: Anti-cancer; Anti-microbial; Anti-oxidant; Butea monosperma.

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Polina, S., Marka, N., & Rao, M.D. (2020). Preliminary Screening of Anti-Microbial, Anti-Oxidant and Anti-Cancer Potential of Butea monosperma Flower Extracts, Ind. J. Pure App. Biosci. 8(6), 442-454. doi: http://dx.doi.org/10.18782/2582-2845.8445