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Indian Journal of Pure & Applied Biosciences (IJPAB)
Year : 2020, Volume : 8, Issue : 4
First page : (46) Last page : (53)
Article doi: : http://dx.doi.org/10.18782/2582-2845.8085

Pathology and Immunohistochemistry of Mammary Tumours in Dogs

Chandravathi Thippani^1* , Anand Kumar² and Mekala Laxman^3
1Assistant Professor, College of Veterinary Science, Rajendranagar, Hyderabad Telangana state, India
²Professor, College of Veterinary Science, Tirupati, Andhrapradesh, India
³Professor, College of Veterinary Science, Rajendranagar, Hyderabad,
Telangana state, India
*Corresponding Author E-mail: chandrakiran13209@gmail.com
Received: 8.05.2020  |  Revised: 14.06.2020   |  Accepted: 23.06.2020 

 ABSTRACT

Mammary tumours were most frequent tumours occurring in dogs. The study was carried to know the incidence and pathology of mammary tumours in dogs. A total of 25 tumour samples collected and analysed histopathologically, they were found to be mammary gland tumours which were further classified as simple adenoma -2, benign mixed mammary tumours-3, tubular adenocarcinoma -3, papillary adenocarcinoma 5, cystic papillary adenocarcinoma 4,  solid carcinoma 2, anaplastic carcinoma 2,  and malignant mixed mammary tumours 4. The highest incidence was noted in an age group of 7-12 years. Tumours were located mostly in the abdominal and inguinal mammary glands and in two cases thoracic mammary glands were involved. Most of tumours were malignant (20). Pure breed dogs were mostly affected. The highest Aygyrophilic nucleolar organizer regions (AgNOR) count and (Proliferating cell nuclear antigen) PCNA index were observed in anaplastic carcinoma while lowest was observed in simple adenoma. A positive correlation was noticed between the PCNA expression and AgNOR counts and these proliferation markers were useful for predicting the outcome of the canine mammary tumours.

Keywords: AgNORs, Dogs, Mammary tumour, Immunohistochemistry, PCNA.

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Thippani, C., Kumar, A., & Laxman, M. (2020). Pathology and Immunohistochemistry of Mammary Tumours in Dogs, Ind. J. Pure App. Biosci. 8(4), 46-53. doi: http://dx.doi.org/10.18782/2582-2845.8085