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Indian Journal of Pure & Applied Biosciences (IJPAB)
Year : 2020, Volume : 8, Issue : 3
First page : (608) Last page : (613)
Article doi: : http://dx.doi.org/10.18782/2582-2845.8128

Stable Intronic Sequence RNAs (sisRNAs): a Newer Insight to Cellular Regulatory Network

Swagatika Priyadarsini^1* , Rohit Singh², Karthikeyan Ramaiyan¹, Arun Somagond³ and Puja Mech^4
1Division of Biochemistry, ²Division of Pathology, ³Livestock Production and Management Section,
⁴Division of Microbiology,
Indian Veterinary Research Institute, Bareilly, UP, India
*Corresponding Author E-mail: drswagatika.vet@gmail.com
Received: 7.05.2020  |  Revised: 13.06.2020   |  Accepted: 18.06.2020 

 ABSTRACT

With the advances in life science sector and its successful collaboration with cutting-edge technologies, newer aspects of cell regulatory pathways are discovered in a progressive manner. Intronic sequences, previously proclaimed as ‘junks’, were subsequently studied in depth to demonstrate their several biological functions and resulted in the discovery of small nucleolar RNA, micro RNA, small cajal body associated RNA, long non coding RNAs etc. In the year 2012, one more milestone was built in this aspect by the innovation of stable intronic sequence RNA (sisRNA) that was isolated from the oocyte cytoplasm of Xenopus tropicalis and confirmed by high-throughput sequencing. Surprisingly, this intronic RNA was found to be stable for a minimum of period of two days and this feature urged the scientists to explore its functional activities. Within half a decade sisRNA was found to be involved in several cellular metabolic activities like embryo development, immunoglobulin evolution, homeostasis maintenance etc. Therefore, this complex molecule can be explored in detail for its exploitation in the field of therapeutics, diagnostics and cancer biomarkers in the future course of work.

Keywords: sisRNA, biomarkers, Xenopus tropicalis, Sequence RNAs

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Priyadarsini, S., Singh, R., Ramaiyan, K., Somagond, A., & Mech, P. (2020). Stable Intronic Sequence RNAs (sisRNAs): a Newer Insight to Cellular Regulatory Network, Ind. J. Pure App. Biosci. 8(3), 608-613. doi: http://dx.doi.org/10.18782/2582-2845.8128