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Indian Journal of Pure & Applied Biosciences (IJPAB)
Year : 2019, Volume : 7, Issue : 4
First page : (298) Last page : (309)
Article doi: : http://dx.doi.org/10.18782/2320-7051.7725

microRNA: An Advance Diagnostic Approach in Tuberculosis

Aditya Upadhyay¹, Anmol Kulshrestha¹, Gopal Patel¹, Mritunjai Singh¹, Deepika Gupta² and Sandeep K. Shrivastava^2*
1School of Biotechnology – Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Road, Bhopal, 462033, India
²Centre for Innovation Research and Development (CIRD), Dr. B. Lal Clinical Laboratories Pvt. Ltd.,
Dr. B. Lal Institute of Biotechnology Jaipur, 302017, India
*Corresponding Author E-mail: ssk.cird1@gmail.com
Received: 5.07.2019  |  Revised: 16.08.2019   |  Accepted: 24.08.2019  

 ABSTRACT

Tuberculosis is the worldwide lethal infectious disease at current days, which is caused by Mycobacterium tuberculosis. microRNA is a small non coding RNA molecule that plays a key role in regulating various biological process. Host microRNA themselves can be up-regulated or down-regulated during disease condition. Potential unique host microRNA might be used as a biomarker in tuberculosis diagnosis at an earlier stage. Therefore, potential host microRNA recognition must be useful in tuberculosis in term of diagnostic purpose. miRNA biomarker field requires more comprehensive work in tuberculosis disease. This review summarizes the biogenesis and biological function of microRNA and various previous and recent studies on recognition of potential biomarker for tuberculosis in case of latent and active tuberculosis. This review also summarizes the role of specific host microRNA in tuberculosis.

Keywords: microRNA, Biogenesis, Tuberculosis, Biomarker.

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Upadhyay, A., Kulshrestha, A., Patel, G., Singh, M., Gupta, D., & Shrivastava, S.K. (2019). microRNA: An Advance Diagnostic Approach in Tuberculosis, Ind. J. Pure App. Biosci. 7(4), 298-309. doi: http://dx.doi.org/10.18782/2320-7051.7725