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International Journal of Pure & Applied Bioscience (IJPAB)
Year : 2018, Volume : 6, Issue : 5
First page : (1304) Last page : (1309)
Article doi: : http://dx.doi.org/10.18782/2320-6793

Dietary Selenium Facilitates Skeletal Muscle Regeneration by Promoting Cell Proliferation

Abhiroopa Ashok Kumar, A. Mangala Gowri*, A. S. Vaishnavi and S. Nandhini

Centre for Stem Cell Research and Regenerative Medicine, Madras Veterinary College, Chennai-7
Tamil Nadu Veterinary and Animal Sciences University, TN, India
*Corresponding Author E-mail: mangalagowri.a@tanuvas.ac.in
Received: 13.08.2018 | Revised: 21.09.2018   | Accepted: 30.09.2018  

 ABSTRACT

Muscle stem cells (satellite cells) are the main contributor to muscle regeneration. Like most stem cells long-term expansion of muscle progenitors in vitro is troublesome. The in vivo muscle regeneration skills are quickly lost when culturing in vitro, that prevents the potential applications of muscle derived cells in cell-based therapies. Selenium is an integral a part of the enzyme antioxidant, that is an inhibitor enzyme that helps to regulate levels of hydrogen peroxide and lipid peroxides that are created throughout normal metabolic activity. Expanded muscle progenitors will replenish the endogenous stem cell pool and can repair multiple rounds of muscle injuries in vivo after a single transplantation. Proliferative ability was estimated by the count and proliferative activity of viable cells employing cell count and enzyme assay at completely different time points after and it has been identified that the proliferative effect of dietary source of selenium on Muscle progenitor cells is dose dependant.

Key words:Muscle progenitor cells, Dietary Selenium – cells – in vitro- dose dependant

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Kumar, A.A., Gowri, A.M., Vaishnavi, A.S. and Nandhini, S., Dietary Selenium Facilitates Skeletal Muscle Regeneration by Promoting Cell Proliferation, Int. J. Pure App. Biosci.6(5): 1304-1309 (2018). doi: http://dx.doi.org/10.18782/2320-7051.6793