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International Journal of Pure & Applied Bioscience (IJPAB)
Year : 2018, Volume : 6, Issue : 2
First page : (1695) Last page : (1699)
Article doi: : http://dx.doi.org/10.18782/2320-7051.6298

Paracrine Interactions of Hepatoma Cells with Endothelial Cell and Fibroblastic Cells

Hamda Siddiqui¹, Preety Rawal¹ and Savneet Kaur^{1, 2}*
¹School of Biotechnology, Gautam Buddha University, UP, India
²Institute of liver and biliary Sciences (ILBS), New Delhi, India
*Corresponding Author E-mail: savykaur@gmail.com
Received: 1.03.2018  |  Revised: 25.03.2018   |  Accepted: 7.04.2018  

 ABSTRACT

Hepatocellular carcinoma (HCC) is one of the most lethal human cancers with a high mortality rate. Various factors can contribute to the genetic alteration of hepatic cells into hepatoma cells, thus leading to HCC. Besides the genetics of tumor cells, tumor microenvironment plays an important role in HCC development and progression. In the current study, we investigated the interactions between hepatic tumor cell lines with endothelial and fibroblastic cells. Results showed that paracrine factors such as platelet-derived growth factor (PDGF) from endothelial cells enhance the proliferation of hepatoma cells. Thus, targeting endothelial cells in HCC could represent a promising therapeutic strategy for HCC.

Key words: Hepatocellular carcinoma (HCC), Endothelial cells, Tumor microenvironment, Paracrine factors, Platelet-derived growth factor

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Siddiqui, H., Rawal, P., Kaur, S., Paracrine Interactions of Hepatoma Cells with Endothelial Cell and Fibroblastic Cells, Int. J. Pure App. Biosci.6(2): 1695-1699 (2018). doi: http://dx.doi.org/10.18782/2320-7051.6298