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Indian Journal of Pure & Applied Biosciences (IJPAB)
Year : 2024, Volume : 12, Issue : 3
First page : (25) Last page : (32)
Article doi: : http://dx.doi.org/10.18782/2582-2845.9071

Proteomic Profiling and in Silico Functional Insights of Whey Protein: Unraveling Molecular Mechanisms for Enhanced Strength, Recovery and Health Benefits

Usha Devi^1* , Rashmeet Kaur², Rohit Kumar Shukla^1
1Animal Biochemistry Division, ICAR-National Dairy Research Institute, Karnal, Haryana, India
²Animal Biotechnology Division, ICAR-National Dairy Research Institute, Karnal,
Haryana, India Haryana, India
*Corresponding Author E-mail: sharmausha3112@gmail.com
Received: 11.02.2024 | Revised: 29.04.2024 | Accepted: 9.05.2024 

 ABSTRACT

Whey protein, a cheese byproduct, is popular for its nutrition and health benefits. This review reviews proteome profiling and in silico functional insights research to understand how whey protein improves strength, recovery, and health. Modern mass spectrometry and chromatography have shown whey protein's complex proteome with many roles. This study synthesizes key findings about whey's physiological effects on proteins involved in muscular strength, recovery, and health. Combining proteome profiling with in silico computational approaches has helped research and predict whey protein activity. Molecular docking and bioinformatics analysis help investigate molecular interactions, pathways, and processes. In silico analyses provide a complete picture of how whey protein influences cellular activities, supplementing experimental results. The research examines how whey protein supplementation impacts muscle strength parameters such as hypertrophy, contractile function, and protein synthesis through molecular mechanisms. The study also analyses immune system modulation, tissue restoration, and anti-inflammatory pathways. It also examines the molecular processes of antioxidant and metabolic regulation in whey protein to determine its health benefits. Whey protein research has progressed, yet issues and knowledge gaps remain. Current challenges include variations in protein composition, proteomic analysis methods, and in silico prediction confirmation. The report concludes with suggestions for future research to better understand whey protein's molecular mechanisms. It stresses the importance of proteomic and computational methods. This paper synthesizes the evidence and provides a comprehensive summary to add to the discussion concerning whey protein's many benefits.

Keywords: Whey protein, Molecular docking, strength, recovery, health

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Devi, U., Kaur, R., Shukla, R. K. (2024). Proteomic Profiling and in Silico Functional Insights of Whey Protein: Unraveling Molecular Mechanisms for Enhanced Strength, Recovery and Health Benefits, Ind. J. Pure App. Biosci. 12(3), 25-32. doi: http://dx.doi.org/10.18782/2582-2845.9071